Cavity-shaped ligands for asymmetric metal catalysis
نویسندگان
چکیده
Cavity-shaped ligands offer unique opportunities for influencing the first sphere of coordination metals because their capacity to act as containers metal centers and/or preorganization platforms. These properties are particular importance in asymmetric catalysis where spatial control around coordinated substrate is paramount reaching high ee values. This perspective article describes different approaches, whether covalent or supramolecular, that have so far been used achieving enantiodiscrimination metal-catalyzed reactions thanks complexation within near chiral capsular environments.
منابع مشابه
Tandem rhodium catalysis: exploiting sulfoxides for asymmetric transition-metal catalysis.
Sulfoxides are uncommon substrates for transition-metal catalysis due to their propensity to inhibit catalyst turnover. In a collaborative effort with Ken Houk, we developed the first dynamic kinetic resolution (DKR) of allylic sulfoxides using asymmetric rhodium-catalyzed hydrogenation. A detailed mechanistic analysis of this transformation using both experimental and theoretical methods revea...
متن کاملIon-paired chiral ligands for asymmetric palladium catalysis.
Conventional chiral ligands rely on the use of a covalently constructed, single chiral molecule embedded with coordinative functional groups. Here, we report a new strategy for the design of a chiral ligand for asymmetric transition-metal catalysis; our approach is based on the development of an achiral cationic ammonium-phosphine hybrid ligand paired with a chiral binaphtholate anion. This ion...
متن کاملNovel Bis-1,3,2-diazaphospholidine Ligands for Asymmetric Catalysis
A family of modularly designed chiral bis-1,3,2-diazaphospholidines with N-aryl substituents (NP-PN) is reported. These compounds have been prepared in two steps from readily available (R,R)-1,2-diaminocyclohexane and tetrachlorodiphosphines. Examples in the set differ in the backbone and the aryl substituents aiming at their application in asymmetric catalysis. Thus, [Rh(NBD)(NP-PN)]BF4 comple...
متن کاملHomochiral metal-organic frameworks for heterogeneous asymmetric catalysis.
Homochiral crystallizations of two enantiomeric metal-organic frameworks (MOFs) Ce-MDIP1 and Ce-MDIP2 were achieved by using L- or D-BCIP as chiral inductions, respectively, where the chiralities were characterized by solid state CD spectra. Ce-MDIPs exhibit excellent catalytic activity and high enantioselectivity for the asymmetric cyanosilylation of aromatic aldehydes; the homochiral Cd-TBT M...
متن کاملNew Applications of Tridentate Bis(oxazoline) Ligands in Asymmetric Catalysis
Finding interactions between microRNAs and their mRNA targets is a challenging experimental and computational problem. While several novel experimental high throughput approaches have been developed for measuring miRNA expression, the amount of data generated from these technologies is dwarfed by the amount of data existing in current gene expression microarray repositories. Many microRNAs over...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Coordination Chemistry Reviews
سال: 2021
ISSN: ['0010-8545', '1873-3840']
DOI: https://doi.org/10.1016/j.ccr.2021.214066